VTP-37948 (BI 1181181) | BACE1 inhibitor

Chemical Structure : VTP-37948

Catalog No.: PC-61040Not For Human Use, Lab Use Only.

VTP-37948 (BI 1181181) is a potent, selective, orally active BACE1 inhibitor for the treatment of Alzheimer's disease.

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Biological Activity

VTP-37948 (BI 1181181) is a potent, selective, orally active BACE1 inhibitor for the treatment of Alzheimer's disease.

M.Wt	412.51
Formula	C23H29FN4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1r,1'R,3R,4R,5S)-2''-amino-1''-(2-fluoro-2-methylpropyl)-4-hydroxy-3,5-dimethyl-5''-oxo-1'',5''-dihydro-3'H-dispiro[cyclohexane-1,2'-indene-1',4''-imidazole]-6'-carbonitrile

1. Bachir Latli, et al. J Labelled Comp Radiopharm. 2023 Apr-May;66(4-6):145-154.