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Chemical Structure : VU0071063
CAS No.: 333415-38-6
Catalog No.: PC-21735Not For Human Use, Lab Use Only.
VU0071063 is a potent and specific Kir6.2/SUR1 opener with EC50 of 7.44 uM, inhibits insulin secretion by inducing hyperpolarization of β-cell membrane potential.
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|---|---|---|---|
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
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| 100 mg | Get quote |
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VU0071063 is a potent and specific Kir6.2/SUR1 opener with EC50 of 7.44 uM, inhibits insulin secretion by inducing hyperpolarization of β-cell membrane potential.
VU0071063 dose dependently opens Kir6.2/SUR1, inhibits glucose-stimulated insulin secretion.
VU0071063 dose dependently and reversibly hyperpolarizes the β-cell membrane potential, inhibits glucose-stimulated Ca2+ entry and insulin secretion.
VU0071063 significant increases blood glucose in vivo.
| M.Wt | 326.40 | |
| Formula | C18H22N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7-(4-(tert-Butyl)benzyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione |
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1. Kharade SV, et al. J Pharmacol Exp Ther. 2019;370(3):350-359.
2. Raphemot R, et al. Mol Pharmacol. 2014;85(6):858-865.
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