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Chemical Structure : VU0152100
CAS No.: 409351-28-6
Catalog No.: PC-43505Not For Human Use, Lab Use Only.
VU0152100 (VU152100) is a potent, selective positive allosteric modulator of M4 mAChR with EC50 of 0.38 uM for rat M4.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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VU0152100 (VU152100) is a potent, selective positive allosteric modulator of M4 mAChR with EC50 of 0.38 uM for rat M4.
VU0152100 potentiates the M4-mediated calcium response calcium response with maximal shifts of 70-fold with 10 uM in vitro assays.
VU0152100 inhibits behavioral and neurochemical effects of cocaine in vivo, also dose-dependently reverses amphetamine-induced hyperlocomotion in rats and wild-type mice, blocks amphetamine-induced disruption of the acquisition of contextual fear conditioning.
| M.Wt | ||
| Formula | C18H19N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethyl- |
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1. Byun NE, et al. Neuropsychopharmacology. 2014 Jun;39(7):1578-93.
2. Brady AE, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):941-53.
3. Dencker D, et al. Psychopharmacology (Berl). 2012 Nov;224(2):277-87.
4. Huynh T, et al. J Med Chem. 2013 Oct 24;56(20):8196-200.
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