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VU0357017 hydrochloride

Chemical Structure : VU0357017 hydrochloride

CAS No.: 1135242-13-5

VU0357017 hydrochloride (VU 0357017 hydrochloride, ML071)

Catalog No.: PC-45705Not For Human Use, Lab Use Only.

VU0357017 hydrochloride (ML071) is a subtype-selective allosteric agonist of M1 receptor with EC50 of 198 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

VU0357017 hydrochloride (ML071) is a subtype-selective allosteric agonist of M1 receptor with EC50 of 198 nM.
VU0357017 displays good selectivity versus M2-M5 and a large panel of GPCRs, ion channels, and transporters.
VU0357017 shows excellent brain exposure and robust in vivo efficacy in rodent model.

Physicochemical Properties

M.Wt 369.8862
Formula C18H28ClN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 33 mg/mL

Chemical Name/SMILES

1-Piperidinecarboxylic acid, 4-[[2-[(2-methylbenzoyl)amino]ethyl]amino]-, ethyl ester, hydrochloride (1:1)

References

1. Lebois EP, et al. ACS Chem Neurosci. 2010;1(2):104-121.

2. Digby GJ, et al. J Neurosci. 2012 Jun 20;32(25):8532-44.

3. Digby GJ, et al. ACS Chem Neurosci. 2012 Dec 19;3(12):1025-36.

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