VU0359595 | PLD1 inhibitor | Probechem Biochemicals

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Chemical Structure : VU0359595

VU0359595 (VU 0359595, ML270)

Catalog No.: PC-72954Not For Human Use, Lab Use Only.

VU0359595 (VU 0359595) is a potent, selective phospholipase D (PLD) inhibitor with cell IC50 of 4 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

VU0359595 (VU 0359595, ML-270) is a potent, selective phospholipase D1 (PLD1) inhibitor with cell IC50 of 4 nM, >1700-fold selective for PLD1 over PLD2.

Physicochemical Properties

M.Wt	497.4
Formula	C25H29BrN4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2R)-N-[(1S)-2-[4-(5-bromo-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl]-2-phenyl-cyclopropanecarboxamide

References

1. Burkhardt U, et al. Neuropharmacology. 2014 Apr;79:1-9.

2. Burkhardt U, et al. Eur J Pharmacol. 2015 Aug 15;761:398-404.

3. Chaves-Moreira D, et al. J Cell Biochem. 2017 Apr;118(4):726-738.

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VU0359595 (VU 0359595, ML270)

Biological Activity

Physicochemical Properties

References

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