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VU 0364849

Chemical Structure : VU 0364849

CAS No.: 1206711-14-9

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VU 0364849 (VU 0364849;DMH2;DMH 2)

Catalog No.: PC-60768Not For Human Use, Lab Use Only.

VU 0364849 (DMH2) is a potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 5.4 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    VU 0364849 (DMH2) is a potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 5.4 nM.
    VU 0364849 also inhibits ALK6 (Ki<1 nM) and ALK2 (Ki=42.77 nM), little to no affinity for ALK4/5, BMPR2, AMPK etc.
    VU 0364849 blocks SMAD phosphorylation in vitro and in vivo, and enhances liver regeneration after partial hepatectomy.

    Physicochemical Properties

    M.Wt 451.53
    Formula C27H25N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(2-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]pyrimidin-6-yl)phenoxy)ethyl)morpholine

    References

    1. Tsugawa D, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):549-58.

    2. Langenfeld E, et al. Mol Cancer. 2013 Oct 26;12(1):129.

    3. Langenfeld E, et al. PLoS One. 2013 Apr 12;8(4):e61256.

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