Catalog No.: PC-21369Not For Human Use, Lab Use Only.
VU 0365114 is a selective type-5 muscarinic acetylcholine receptor (mAChR, M5) positive allosteric modulator (EC50=2.7 uM) and tubulin inhibitor by destabilizing microtubules, shows no activity against M1, M2, M3 and M4 receptors.
VU 0365114 is a selective type-5 muscarinic acetylcholine receptor (mAChR, M5) positive allosteric modulator (EC50=2.7 uM) and tubulin inhibitor by destabilizing microtubules, shows no activity against M1, M2, M3 and M4 receptors. VU-0365114 exhibits a broad-spectrum in vitro anticancer activity, especially in colorectal cancer cells. VU-0365114 slows the in vivo colorectal tumor growth in tumor xenograft study in nude mice. VU 0365114 significantly increased electrically evoked DA release and the Oxo-M effect on DA release.
