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Chemical Structure : VU 0365114
CAS No.: 1208222-39-2
Catalog No.: PC-21369Not For Human Use, Lab Use Only.
VU 0365114 is a selective type-5 muscarinic acetylcholine receptor (mAChR, M5) positive allosteric modulator (EC50=2.7 uM) and tubulin inhibitor by destabilizing microtubules, shows no activity against M1, M2, M3 and M4 receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 100 mg | Get quote |
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VU 0365114 is a selective type-5 muscarinic acetylcholine receptor (mAChR, M5) positive allosteric modulator (EC50=2.7 uM) and tubulin inhibitor by destabilizing microtubules, shows no activity against M1, M2, M3 and M4 receptors.
VU-0365114 exhibits a broad-spectrum in vitro anticancer activity, especially in colorectal cancer cells.
VU-0365114 slows the in vivo colorectal tumor growth in tumor xenograft study in nude mice.
VU 0365114 significantly increased electrically evoked DA release and the Oxo-M effect on DA release.
| M.Wt | 397.35 | |
| Formula | C22H14F3NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-([1,1'-Biphenyl]-4-ylmethyl)-5-(trifluoromethoxy)indoline-2,3-dione |
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1. Vivien Zell , et al. J Pharmacol Exp Ther. 2023 Nov;387(2):226-234.
2. Hsieh YY, et al. Mol Oncol. 2023 Oct 16. doi: 10.1002/1878-0261.13536.
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