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Chemical Structure : VU0405601
Catalog No.: PC-60841Not For Human Use, Lab Use Only.
VU0405601 is a potent Kv11.1 (hERG) channel allosteric modulator that protects cardiac tissue from hERG-related drug-induced arrhythmias.
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VU0405601 is a potent Kv11.1 (hERG) channel allosteric modulator that protects cardiac tissue from hERG-related drug-induced arrhythmias.
VU0405601 increases the IC(50) of dofetilide from 38.7 to 76.3 nM, mitigates the effects of hERG blockers from the extracellular aspect primarily by reducing inactivation.
VU0405601 reduces the sensitivity of hERG to inhibitors.
| M.Wt | 357.207 | |
| Formula | C17H13BrN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Potet F, et al. J Biol Chem. 2012 Nov 16;287(47):39613-25.
2. Yu Z, et al. Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e003439.
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