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Chemical Structure : VU0405645
Catalog No.: PC-49070Not For Human Use, Lab Use Only.
VU0405645 is a potent, biased M1 receptor-positive allosteric modulator, potentiates Ca2+ mobilization in CHO cells stably expressing the M1 receptor with EC50 of 340 nM.
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VU0405645 is a potent, biased M1 receptor-positive allosteric modulator, potentiates Ca2+ mobilization in CHO cells stably expressing the M1 receptor with EC50 of 340 nM.
VU0405645 does not potentiate the CCh-dependent activation of PLD in in vitro assay.
VU0405645 potentiates agonist-induced increases in spontaneous excitatory postsynaptic currents (sEPSCs).
VU0405645 potentiates an increase in SPN excitability in response to a submaximal concentration of CCh.
| M.Wt | 511.504 | |
| Formula | C24H19F2N5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sean P Moran, et al. Sci Signal. 2019 Dec 3;12(610):eaax2057.
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