Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-GPCR-mAChR-VU0405645
VU0405645

Chemical Structure : VU0405645

CAS No.: 1222886-16-9

Add to Favorites

VU0405645 (VU 0405645)

Catalog No.: PC-49070Not For Human Use, Lab Use Only.

VU0405645 is a potent, biased M1 receptor-positive allosteric modulator, potentiates Ca2+ mobilization in CHO cells stably expressing the M1 receptor with EC50 of 340 nM.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    VU0405645 is a potent, biased M1 receptor-positive allosteric modulator, potentiates Ca2+ mobilization in CHO cells stably expressing the M1 receptor with EC50 of 340 nM.
    VU0405645 does not potentiate the CCh-dependent activation of PLD in in vitro assay.
    VU0405645 potentiates agonist-induced increases in spontaneous excitatory postsynaptic currents (sEPSCs).
    VU0405645 potentiates an increase in SPN excitability in response to a submaximal concentration of CCh.

    Physicochemical Properties

    M.Wt 511.504
    Formula C24H19F2N5O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-[4,6-difluoro-1-[3-(1H-pyrazol-4-yl)benzyl]indol-3-yl]sulfonyl-N-(5-methylisoxazol-3-yl)acetamide

    References

    1. Sean P Moran, et al. Sci Signal. 2019 Dec 3;12(610):eaax2057.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: