VU 0463271 is a potent, selecitve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 61 nM.
VU 0463271 displays >100-fold selectivity versus NKCC1 (>100 uM), no significant activities on a panel of 68 GPCRs, ion channels and transporters.
VU 0463271 exhibts 9-times more potent than ML077, and maintains an excellent ancillary pharmacology profile.
