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VU 0463271

Chemical Structure : VU 0463271

CAS No.: 1391737-01-1

VU 0463271 (VU0463271)

Catalog No.: PC-62063Not For Human Use, Lab Use Only.

VU 0463271 is a potent, selecitve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 61 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

VU 0463271 is a potent, selecitve inhibitor of the neuronal K-Cl cotransporter KCC2 with IC50 of 61 nM.
VU 0463271 displays >100-fold selectivity versus NKCC1 (>100 uM), no significant activities on a panel of 68 GPCRs, ion channels and transporters.
VU 0463271 exhibts 9-times more potent than ML077, and maintains an excellent ancillary pharmacology profile.

Physicochemical Properties

M.Wt 382.5
Formula C19H18N4OS2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide

References

1. Delpire E, et al. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5383-8.

2. Delpire E, et al. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4532-5.

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