VU 0465350 |CAS:1414843-61-0 Probechem Biochemicals

Chemical Structure : VU 0465350

VU 0465350 (VU0465350;VU5350;VU 5350)

Catalog No.: PC-60769Not For Human Use, Lab Use Only.

VU 0465350 is a potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 92.3 nM.

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Biological Activity

VU 0465350 is a potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 92.3 nM.
VU 0465350 shows no activity for ALK2/4/5, also shows affinity for TGFBR2, VEGFR2 and AMPK.
VU 0465350 blocks SMAD phosphorylation in vitro and in vivo, and enhances liver regeneration after partial hepatectomy.

Physicochemical Properties

M.Wt	318.38
Formula	C19H18N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(4-isopropoxyphenyl)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyridine

References

1. Tsugawa D, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):549-58.

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VU 0465350 (VU0465350;VU5350;VU 5350)

Biological Activity

Physicochemical Properties

References

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