VU0466551 |CAS:1448705-06-3 Probechem Biochemicals

Chemical Structure : VU0466551

VU0466551 (VU 0466551;VU-0466551)

Catalog No.: PC-35863Not For Human Use, Lab Use Only.

VU0466551 (VU-0466551) is a potent, selective, small-molecule GIRK activator with EC50 of 70.6 nM (GIRK1/2 channels).

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Biological Activity

VU0466551 (VU-0466551) is a potent, selective, small-molecule GIRK activator with EC50 of 70.6 nM (GIRK1/2 channels).
VU0466551 demonstrates analgesic effects when dosed alone or in combination with sub-maximally effective doses of morphine.

Physicochemical Properties

M.Wt	342.35
Formula	C18H16F2N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(1-benzyl-3-methyl-1H-pyrazol-5-yl)-3-(3,4-difluorophenyl)urea

References

1. Abney KK, et al. ACS Chem Neurosci. 2018 Nov 26. doi: 10.1021/acschemneuro.8b00370.

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VU0466551 (VU 0466551;VU-0466551)

Biological Activity

Physicochemical Properties

References

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