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Chemical Structure : VU0467154
CAS No.: 1451993-15-9
Catalog No.: PC-35489Not For Human Use, Lab Use Only.
VU0467154 (VU 0467154) is a potent, selective M4 mAChR positive allosteric modulator with EC50 of 17.7 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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VU0467154 (VU 0467154) is a potent, selective M4 mAChR positive allosteric modulator with EC50 of 17.7 nM.
VU0467154 produces a robust dose-dependent reversal of MK-801-induced hyperlocomotion and deficits in preclinical models of associative learning and memory functions, including the touchscreen pairwise visual discrimination task in wild-type mice.
VU0467154 also enhances the acquisition of both contextual and cue-mediated fear conditioning.
| M.Wt | 444.447 | |
| Formula | C17H15F3N4O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-Amino-3,4-dimethyl-N-[[4-[(trifluoromethyl)sulfonyl]phenyl]methyl]thieno[2,3-c]pyridazine-6-carboxamide |
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1. Bubser M, et al. ACS Chem Neurosci. 2014 Oct 15;5(10):920-42.
2. Pancani T, et al. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14078-83.
3. Gould RW, et al. Neuropharmacology. 2016 Mar;102:244-53.
4. Foster DJ, et al. Neuron. 2016 Sep 21;91(6):1244-1252.
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