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Chemical Structure : VU0467485
CAS No.: 1451994-10-7
Catalog No.: PC-35946Not For Human Use, Lab Use Only.
VU0467485 (VU-0467485, AZ13713945) is potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 (M4) positive allosteric modulator with EC50 of 78.8 nM (hM4).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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VU0467485 (VU-0467485, AZ13713945) is potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 (M4) positive allosteric modulator with EC50 of 78.8 nM (hM4).
VU0467485 possesses robust in vitro M4 PAM potency across species and in vivo efficacy in preclinical models of schizophrenia.
| M.Wt | 360.407 | |
| Formula | C17H17FN4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide |
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1. Wood MR, et al. ACS Med Chem Lett. 2016 Dec 16;8(2):233-238.
2. Melancon BJ, et al. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2296-2301.
3. Deng X, et al. ChemMedChem. 2018 Dec 27. doi: 10.1002/cmdc.201800710.
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