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Chemical Structure : VU0468554
Catalog No.: PC-72820Not For Human Use, Lab Use Only.
VU0468554 (VU 0468554) is a potent, selective inhibitor of GIRK channel with IC50 of 0.85 and 2.6 uM for GIRK1/GIRK4 and GIRK1/GIRK2 in cellular assays.
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VU0468554 (VU 0468554) is a potent, selective inhibitor of GIRK channel with IC50 of 0.85 and 2.6 uM for GIRK1/GIRK4 and GIRK1/GIRK2 in cellular assays.
VU0468554 more effectively inhibits the cardiac GIRK channel than the neuronal GIRK channel, inhibits Gβγ-activated GIRK channels in noncompetitive and potentially uncompetitive fashion.
VU0468554 competitively inhibits GIRK-channel activation by ML297, a GIRK-channel activator.
In the isolated heart model, VU0468554 partially reversed carbachol-induced bradycardia in hearts from wild-type mice but not Girk4-/- mice.
| M.Wt | 334.423 | |
| Formula | C20H22N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO (3.34 mg/mL) |
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1. Allison Anderson, et al. Mol Pharmacol. 2021 Dec;100(6):540-547.
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