Chemical Structure : VU0481443
CAS No.:
1627138-52-6
VU0481443
(ML380, VU 0481443)
Catalog No. : PC-62140Not For Human Use, Lab Use Only.
VU0481443 (ML380) is a potent, selective and CNS penetrant M5 positive allosteric modulator (PAM) with EC50 of 190 nM for hM5.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6214001
Biological Activity
VU0481443 (ML380) is a potent, selective and CNS penetrant M5 positive allosteric modulator (PAM) with EC50 of 190 nM for hM5.
Physicochemical Properties
M.Wt
494.533
Formula
C23H25F3N4O3S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide
References
1. Gentry PR, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
2. Berizzi AE, et al. Mol Pharmacol
3. Gentry PR, et al. J Med Chem
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