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Chemical Structure : VU0481443
CAS No.: 1627138-52-6
Catalog No.: PC-62140Not For Human Use, Lab Use Only.
VU0481443 (ML380) is a potent, selective and CNS penetrant M5 positive allosteric modulator (PAM) with EC50 of 190 nM for hM5.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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VU0481443 (ML380) is a potent, selective and CNS penetrant M5 positive allosteric modulator (PAM) with EC50 of 190 nM for hM5.
VU0481443 dispalys >10-fold selectivity over M1 and M3, >100-fold selectivity over M2 and M4;.
VU0481443 is an useful in vivo tool compound.
| M.Wt | 494.533 | |
| Formula | C23H25F3N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide |
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1. Gentry PR, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
2. Berizzi AE, et al. Mol Pharmacol. 2016 Oct;90(4):427-36.
3. Gentry PR, et al. J Med Chem. 2014 Sep 25;57(18):7804-10.
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