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VU0486846

Chemical Structure : VU0486846

CAS No.: 1788055-11-7

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VU0486846 (VU 0486846)

Catalog No.: PC-63463Not For Human Use, Lab Use Only.

VU0486846 is a potent, highly selective M1 mAChR positive allosteric modulation (PAM) with EC50 of 0.31 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    VU0486846 is a potent, highly selective M1 mAChR positive allosteric modulation (PAM) with EC50 of 0.31 uM.
    VU0486846 possesses only weak agonist activity in M1-expressing cell lines with high receptor reserve and is devoid of agonist actions in the prefrontal cortex (PFC), shows no interaction with antagonist binding at the orthosteric acetylcholine (ACh) site.
    VU0486846 produces robust efficacy in the novel object recognition model of cognitive function.

    Physicochemical Properties

    M.Wt 432.524
    Formula C25H28N4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-4-(4-(1H-pyrazol-1-yl)benzyl)-N-((1S,2S)-2-hydroxycyclohexyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide

    References

    1. Rook JM, et al. ACS Chem Neurosci. 2018 Apr 27. doi: 10.1021/acschemneuro.8b00131.

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