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VU0506013

Chemical Structure : VU0506013

CAS No.: 1207036-87-0

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VU0506013 (VU 0506013)

Catalog No.: PC-20970Not For Human Use, Lab Use Only.

VU0506013 is a high-affinity, selective positive allosteric modulator (PAM) of neuropeptide Y4 receptor (Y4R) with EC50 of 125 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

VU0506013 is a high-affinity, selective positive allosteric modulator (PAM) of neuropeptide Y4 receptor (Y4R) with EC50 of 125 nM.
VU0506013 shows high affinity (KB=34.9 nM) to the allosteric binding site at the Y4R. does not affect the binding of the endogenous ligand PP to the Y4R.
VU0506013 displays no significant effect against Y1R, Y2R, and Y5R using the Ca2+ flux assays.
VU0506013 shows a high binding affinity to the rY4R and mY4R with KB values of 75.9 and 229 nM, respectively.

Physicochemical Properties

M.Wt 369.42
Formula C20H23N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(NC1=CC(C(N2CCCC2)=O)=CN(C)C1=O)COC3=CC=CC=C3C

References

1. Corinna Schüß, et al. J Med Chem. 2023 Jun 20. doi: 10.1021/acs.jmedchem.3c00383.

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