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Chemical Structure : VU 10010
CAS No.: 633283-39-3
Catalog No.: PC-62160Not For Human Use, Lab Use Only.
VU 10010 is a selective, allosteric potentiator of M4 mAChR (EC50=33 and 0.7 nM for ACh in the absence and presence of VU10010 respectively), has no activity at other mAChR subtypes.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $168 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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VU 10010 is a selective, allosteric potentiator of M4 mAChR (EC50=33 and 0.7 nM for ACh in the absence and presence of VU10010 respectively), has no activity at other mAChR subtypes.
VU 10010 binds to an allosteric site on the receptor increasing affinity for ACh and coupling to G-proteins.
VU 10010 increases carbachol-induced depression of transmission at excitatory but not inhibitory synapses in the hippocampus.
| M.Wt | 345.845 | |
| Formula | C17H16ClN3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-amino-N-(4-chlorobenzyl)-4, 6-dimethylthieno[2,3-b]pyridine-2-carboxamide |
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1. Shirey JK, et al. Nat Chem Biol. 2008 Jan;4(1):42-50.
2. Brady AE, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):941-53.
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