VU533 | NAPE-PLD activator | Probechem Biochemicals

Chemical Structure : VU533

VU533 (VU 533)

Catalog No.: PC-20922Not For Human Use, Lab Use Only.

VU533 is a small molecule activator of N-acyl-phosphatidylethanolamine hydrolyzing phospholipase D (NAPE-PLD) with EC50 of 0.3 uM, enhances efferocytosis by macrophages.

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Biological Activity

VU533 is a small molecule activator of N-acyl-phosphatidylethanolamine hydrolyzing phospholipase D (NAPE-PLD) with EC50 of 0.3 uM, enhances efferocytosis by macrophages.
VU533 (10 uM) increases the NAPE-PLD activity of RAW264.7 macrophages.
VU533 enhances efferocytosis in a NAPE-PLD-dependent manner in bone-marrow derived macrophages (BMDM).

Physicochemical Properties

M.Wt	447.54
Formula	C21H22FN3O3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(C1CCN(S(=O)(C2=CC=C(F)C=C2)=O)CC1)NC3=NC4=C(C)C=CC(C)=C4S3

References

1. Jonah E Zarrow, et al. bioRxiv. 2023 Feb 28;2023.01.25.525554.

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VU533 (VU 533)

Biological Activity

Physicochemical Properties

References

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