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Chemical Structure : VU590 dihydrochloride
CAS No.: 1783987-83-6
Catalog No.: PC-60570Not For Human Use, Lab Use Only.
VU590 is the first small-molecule inhibitor of renal outer medullary potassium channel (ROMK, Kir1.1) and Kir7.1 with IC50 of 294 nM for ROMK.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $498 | In stock | |
| 100 mg | Get quote |
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VU590 is the first small-molecule inhibitor of renal outer medullary potassium channel (ROMK, Kir1.1) and Kir7.1 with IC50 of 294 nM for ROMK.
VU590 also inhibits inwardly rectifying K+ channel Kir7.1 (IC50=5.6 uM), but has no activity for Kir2.1 or Kir4.1.
VU590 induces profound, long-lasting contractions in mouse and human myometrium.
| M.Wt | 561.46 | |
| Formula | C24H32N4O7.2HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7,13-Bis[(4-nitrophenyl)methyl]-1,4,10-trioxa-7,13-diazacyclopentadecane dihydrochloride |
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1. Lewis LM, et al. Mol Pharmacol. 2009 Nov;76(5):1094-103.
2. Bhave G, et al. Mol Pharmacol. 2011 Jan;79(1):42-50.
3. McCloskey C, et al. EMBO Mol Med. 2014 Sep;6(9):1161-74.
4. Kharade SV, et al. Mol Pharmacol. 2017 Sep;92(3):338-346.
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