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Chemical Structure : VU591
CAS No.: 1222810-74-3
Catalog No.: PC-60571Not For Human Use, Lab Use Only.
VU591 is a potent, selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 0.24 uM in T1+ flux assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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VU591 is a potent, selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 0.24 uM in T1+ flux assays.
VU591 has no effect on Kir7.1 at 10 uM, does not inhibit Kir2.1, Kir2.3 and Kir4.1, 150-fold selectivity over Kir6.2/SUR1.
VU591 blocks the intracellular pore of the channel and is a useful probe to explore the viability of ROMK as a diuretic target.
| M.Wt | 368.309 | |
| Formula | C16H12N6O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2,2'-(oxybis(methylene))bis(6-nitro-1H-benzo[d]imidazole) |
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1. Bhave G, et al. Mol Pharmacol. 2011 Jan;79(1):42-50.
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