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VU591

Chemical Structure : VU591

CAS No.: 1222810-74-3

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VU591 (VU-591, VU 591)

Catalog No.: PC-60571Not For Human Use, Lab Use Only.

VU591 is a potent, selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 0.24 uM in T1+ flux assays.

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5 mg $58 In stock
10 mg $88 In stock
25 mg $138 In stock
50 mg $218 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

VU591 is a potent, selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 0.24 uM in T1+ flux assays.
VU591 has no effect on Kir7.1 at 10 uM, does not inhibit Kir2.1, Kir2.3 and Kir4.1, 150-fold selectivity over Kir6.2/SUR1.
VU591 blocks the intracellular pore of the channel and is a useful probe to explore the viability of ROMK as a diuretic target.

Physicochemical Properties

M.Wt 368.309
Formula C16H12N6O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,2'-(oxybis(methylene))bis(6-nitro-1H-benzo[d]imidazole)

References

1. Bhave G, et al. Mol Pharmacol. 2011 Jan;79(1):42-50.

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