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Chemical Structure : VU6004256
Catalog No.: PC-35486Not For Human Use, Lab Use Only.
VU6004256 (VU 6004256) is a highly potent, selective M1 muscarinic acetylcholine receptor (mAChR) positive allosteric modulator with EC50 of 155 nM (mouse M1), significant selectivity over M2-M5 (EC50>30 uM).
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VU6004256 (VU 6004256) is a highly potent, selective M1 muscarinic acetylcholine receptor (mAChR) positive allosteric modulator with EC50 of 155 nM (mouse M1), significant selectivity over M2-M5 (EC50>30 uM).
VU6004256 normalizes deficits in muscarinic agonist-induced long-term depression in layer V of the PFC in the NR1 KD mice.
VU6004256 also reduces excessive pyramidal neuron firing in layer V PFC neurons in awake.
VU6004256 produces a robust, dose-dependent reduction in the hyperlocomotor activity in vivo.
| M.Wt | 465.505 | |
| Formula | C25H25F2N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Grannan MD, et al. ACS Chem Neurosci. 2016 Dec 21;7(12):1706-1716.
2. Khajehali E, et al. Biochem Pharmacol. 2018 Aug;154:243-254.
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