VU6007477 | M1 mAChR PAM | Probechem Biochemicals

Chemical Structure : VU6007477

CAS No.: 2220141-46-6

VU6007477 (VU 6007477)

Catalog No.: PC-35747Not For Human Use, Lab Use Only.

VU6007477 is a potent, selective, CNS penetrant M1 positive allosteric modulator (PAM) with EC50 of 230 nM, 93% ACh max with minimal M1 agonist activity.

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5 mg	$348	In stock
10 mg	$548	In stock
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Biological Activity

VU6007477 is a potent, selective, CNS penetrant M1 positive allosteric modulator (PAM) with EC50 of 230 nM, 93% ACh max with minimal M1 agonist activity.
VU6007477 displays high selectivity against M2-M5.

Physicochemical Properties

M.Wt	430.512
Formula	C24H26N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-methyl-4-((6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)methyl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrrolo[2,3-b]pyridine-6-carboxamide

References

1. Engers JL, et al. ACS Med Chem Lett. 2018 Sep 4;9(9):917-922.

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VU6007477 (VU 6007477)

Biological Activity

Physicochemical Properties

References

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