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Chemical Structure : VU6007496
Catalog No.: PC-22961Not For Human Use, Lab Use Only.
VU6007496 is a highly selective and CNS penetrant M1 mAChR positive allosteric modulator (PAM) with EC50 of 228 nM (hM1), with minimal M1 agonism (EC50>10 μM).
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VU6007496 is a highly selective and CNS penetrant M1 mAChR positive allosteric modulator (PAM) with EC50 of 228 nM (hM1), with minimal M1 agonism (EC50>10 μM).
VU6007496 is inactive on human and rat M2–5 (EC50s > 30 μM).
VU6007496 dose-dependently enhanced recognition memory in rats with a minimum effective dose (MED) of 3 mg/kg p.o.
| M.Wt | 429.52 | |
| Formula | C25H27N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Julie L. Engers, et al. ACS Chemical Neuroscience, August 28, 2024
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