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Chemical Structure : VU6007678
Catalog No.: PC-63491Not For Human Use, Lab Use Only.
VU6007678 is a potent, subtype selective, CNS penetrant M5 mAChR positive allosteric modulator (PAM) with EC50 of 41 nM.
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VU6007678 is a potent, subtype selective, CNS penetrant M5 mAChR positive allosteric modulator (PAM) with EC50 of 41 nM.
VU6007678 displays little to no activity at human M1(EC50=1034 nM), M2 (inactive), M3 (EC50=466 nM), M4 (inactive).
VU6007678 shows potentiating ACh signaling efficacy and robust allosteric agonist activity.
| M.Wt | 484.59 | |
| Formula | C25H29FN4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Berizzi AE, et al. ACS Chem Neurosci. 2018 Apr 30. doi: 10.1021/acschemneuro.8b00136.
3. Bender AM, et al. ACS Chem Neurosci. 2018 Apr 26. doi: 10.1021/acschemneuro.8b00126.
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