Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-GPCR-mAChR-VU6007678
VU6007678

Chemical Structure : VU6007678

CAS No.: 2222737-15-5

Add to Favorites

VU6007678 (VU 6007678)

Catalog No.: PC-63491Not For Human Use, Lab Use Only.

VU6007678 is a potent, subtype selective, CNS penetrant M5 mAChR positive allosteric modulator (PAM) with EC50 of 41 nM.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    VU6007678 is a potent, subtype selective, CNS penetrant M5 mAChR positive allosteric modulator (PAM) with EC50 of 41 nM.
    VU6007678 displays little to no activity at human M1(EC50=1034 nM), M2 (inactive), M3 (EC50=466 nM), M4 (inactive).
    VU6007678 shows potentiating ACh signaling efficacy and robust allosteric agonist activity.

    Physicochemical Properties

    M.Wt 484.59
    Formula C25H29FN4O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-1-((1H-indazol-5-yl)sulfonyl)-N-(4-fluoro-2,3-dihydro-1H-inden-1-yl)-N-propylpiperidine-4-carboxamide

    References

    1. Berizzi AE, et al. ACS Chem Neurosci. 2018 Apr 30. doi: 10.1021/acschemneuro.8b00136.

    3. Bender AM, et al. ACS Chem Neurosci. 2018 Apr 26. doi: 10.1021/acschemneuro.8b00126.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: