VU 6008667 |CAS:2092923-21-0 Probechem Biochemicals

Chemical Structure : VU 6008667

VU 6008667 (VU6008667)

Catalog No.: PC-62118Not For Human Use, Lab Use Only.

VU 6008667 is a potent, highly selective M5 negative allosteric modulator with IC50 of 1.2 uM.

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Biological Activity

VU 6008667 is a potent, highly selective M5 negative allosteric modulator with IC50 of 1.2 uM.
VU 6008667 shows high CNS penetration, excellent selectivity versus M1-4 and the desired short half-life (t1/2=2.3h) in rats.

Physicochemical Properties

M.Wt	438.859
Formula	C24H17ClF2N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5H-Imidazo[2,1-a]isoindol-5-one, 9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-, (9bS)-

References

1. McGowan KM, et al. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359.

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VU 6008667 (VU6008667)

Biological Activity

Physicochemical Properties

References

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