VU6015929 (VU 6015929) is a potent, selective, dual DDR1/2 inhibitor with IC50 of 4.67 nM and 7.39 nM for DDR1 and DDR2, respectively.
VU6015929 displays low cytotoxicity, good kinome selectivity, and possessing an acceptable in vitro DMPK profile with good rodent in vivo pharmacokinetics.
VU6015929 blocks collagen I-induced DDR1 autophosphorylation in DDR1 expressing cells, also blocks collagen IV production in a DDR1 dependent manner.
