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VU6015929

Chemical Structure : VU6015929

CAS No.: 2442597-56-8

VU6015929 (VU 6015929)

Catalog No.: PC-72924Not For Human Use, Lab Use Only.

VU6015929 (VU 6015929) is a potent, selective, dual DDR1/2 inhibitor with IC50 of 4.67 nM and 7.39 nM for DDR1 and DDR2, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

VU6015929 (VU 6015929) is a potent, selective, dual DDR1/2 inhibitor with IC50 of 4.67 nM and 7.39 nM for DDR1 and DDR2, respectively.
VU6015929 displays low cytotoxicity, good kinome selectivity, and possessing an acceptable in vitro DMPK profile with good rodent in vivo pharmacokinetics.
VU6015929 blocks collagen I-induced DDR1 autophosphorylation in DDR1 expressing cells, also blocks collagen IV production in a DDR1 dependent manner.

Physicochemical Properties

M.Wt 485.443
Formula C24H19F4N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-fluoro-3-(((5-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)methyl)amino)-N-(3-(trifluoromethoxy)phenyl)benzamide

References

1. Jeffries DE, et al. ACS Med Chem Lett. 2019 Nov 25;11(1):29-33.

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