Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : VU6015929
CAS No.: 2442597-56-8
Catalog No.: PC-72924Not For Human Use, Lab Use Only.
VU6015929 (VU 6015929) is a potent, selective, dual DDR1/2 inhibitor with IC50 of 4.67 nM and 7.39 nM for DDR1 and DDR2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $218 | In stock | |
| 10 mg | $358 | In stock | |
| 25 mg | $548 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
VU6015929 (VU 6015929) is a potent, selective, dual DDR1/2 inhibitor with IC50 of 4.67 nM and 7.39 nM for DDR1 and DDR2, respectively.
VU6015929 displays low cytotoxicity, good kinome selectivity, and possessing an acceptable in vitro DMPK profile with good rodent in vivo pharmacokinetics.
VU6015929 blocks collagen I-induced DDR1 autophosphorylation in DDR1 expressing cells, also blocks collagen IV production in a DDR1 dependent manner.
| M.Wt | 485.443 | |
| Formula | C24H19F4N5O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-fluoro-3-(((5-(1-methyl-1H-pyrazol-3-yl)pyridin-3-yl)methyl)amino)-N-(3-(trifluoromethoxy)phenyl)benzamide |
|
1. Jeffries DE, et al. ACS Med Chem Lett. 2019 Nov 25;11(1):29-33.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
