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Chemical Structure : VU6019650
Catalog No.: PC-73364Not For Human Use, Lab Use Only.
VU6019650 is a potent, highly selective M5 mAChR orthosteric antagonist with IC50 of 36 nM, >100-fold selectivity against human M1-4.
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VU6019650 is a potent, highly selective M5 mAChR orthosteric antagonist with IC50 of 36 nM, >100-fold selectivity against human M1-4.
VU6019650 blocked the nonselective muscarinic agonist oxotremorine-M-induced increases in neuronal firing rates of midbrain dopamine neurons in the ventral tegmental area.
VU6019650 also inhibited oxycodone self-administration in male Sprague-Dawley rats without impair general motor output.
| M.Wt | 411.510 | |
| Formula | C18H22FN3O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Aaron T Garrison, et al. J Med Chem. 2022 Apr 13. doi: 10.1021/acs.jmedchem.2c00192.
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