Chemical Structure : VU6025733
CAS No.:
VU6025733
(AG06827)
Catalog No.: PC-26253Not For Human Use, Lab Use Only.
VU6025733 (AG06827) is a highly selective, orally bioavailable M4 muscarinic acetylcholine receptor (M4 mAChR) positive allosteric modulator (PAM) with EC50 of 23 nM and 55 nM for hM4 and rM4 respectively.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
VU6025733 (AG06827) is a highly selective, orally bioavailable M4 muscarinic acetylcholine receptor (M4 mAChR) positive allosteric modulator (PAM) with EC50 of 23 nM and 55 nM for hM4 and rM4 respectively.
VU6025733 exhibited no appreciable species differences in M4 activity between human and rat (∼2-fold).
VU6025733 is inactive against other subtypes of muscarinic acetylcholine receptors (M1, M2, M3, and M5).
VU6025733 demonstrated a robust dose-dependent blockade of amphetamine-induced hyperlocomotion (AHL) after oral administration following a 30 min pretreatment interval in rats (MED=10 mg/kg).
Physicochemical Properties
|
M.Wt
|
386.47
|
|
Formula
|
C20H18D5N5O3
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
6-(4-((2,3-Dihydrobenzo[b][1,4]dioxin-6-yl-2,2,3,3-d4)oxy)piperidin-1-yl-4-d)-7,8-dimethyl-[1,2,4]triazolo[4,3-b]pyridazine
|
References
1. Gregro AR, et al. ACS Chem Neurosci. 2026 Feb 4;17(3):649-665.
Contact Us
sales@probechem.com
