VU6032735 | SLO3 inhibitor | Probechem Biochemicals

Chemical Structure : VU6032735

VU6032735 (VU-6032735)

Catalog No.: PC-25544Not For Human Use, Lab Use Only.

VU6032735 is a highly potent, subtype-selective sperm-specific potassium channel 3 (SLO3) inhibitor with IC50 of 165 nM (hSLO3), 172-fold selective over hERG.

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Biological Activity

VU6032735 is a highly potent, subtype-selective sperm-specific potassium channel 3 (SLO3) inhibitor with IC50 of 165 nM (hSLO3), 172-fold selective over hERG.
VU6032735 inhibits mouse SLO3 currents with IC50 of 730 nM.

Physicochemical Properties

M.Wt	525.45
Formula	C25H21F6N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-((4-(trifluoromethoxy)benzyl)oxy)phenyl)(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)methanone

References

1. Temple KJ, et al. ACS Pharmacol Transl Sci. 2025 Aug 15;8(9):3281-3295.

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VU6032735 (VU-6032735)

Biological Activity

Physicochemical Properties

References

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