VU6036864 | M5 mAChR antagonist | Probechem Biochemicals

Chemical Structure : VU6036864

VU6036864 (VU 6036864)

Catalog No.: PC-22893Not For Human Use, Lab Use Only.

VU6036864 is a highly potent, selective antagonist of muscarinic acetylcholine receptor mAChR subtype 5 (M5) with IC50 of 25 nM (hM5), >500 fold selectivity against M1-4 receptors.

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Biological Activity

VU6036864 is a highly potent, selective antagonist of muscarinic acetylcholine receptor mAChR subtype 5 (M5) with IC50 of 25 nM (hM5), >500 fold selectivity against M1-4 receptors.
VU6036864 exhibited good potency, subtype selectivity, and oral DMPK properties.

Physicochemical Properties

M.Wt	385.86
Formula	C15H12D4ClN5O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((4-(7-chloro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)piperidin-1-yl-2,2,6,6-d4)sulfonyl)-2-methyloxazole

References

1. Jinming Li, et al. J Med Chem. 2024 Aug 6. doi: 10.1021/acs.jmedchem.4c01193.

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VU6036864 (VU 6036864)

Biological Activity

Physicochemical Properties

References

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