VU6045422

Chemical Structure : VU6045422

Catalog No.: PC-24341Not For Human Use, Lab Use Only.

VU6045422 is a potent, selective M1 positive allosteric modulator (PAM) with EC50 of 192 nM, 80% ACh Max (hM1).

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Biological Activity

VU6045422 is a potent, selective M1 positive allosteric modulator (PAM) with EC50 of 192 nM, 80% ACh Max (hM1).
VU6045422 does not induce a significant long-term depression of fEPSPs in the mouse layer 5 prefrontal cortex.
VU6045422 was significantly more stable than VU0467319, but was found less stable in liver microsomes.

Physicochemical Properties

M.Wt	395.42
Formula	C22H11D5F2N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(2,6-difluoro-4-(2-(methyl-d3)-2H-indazol-4-yl)benzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one-7,7-d2

References

1. Engers JL, et al. ACS Chem Neurosci. 2025 Mar 25. doi: 10.1021/acschemneuro.5c00119.

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VU6045422

Biological Activity

Physicochemical Properties

References

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