VU6047534 | 5-HT2B agonist | Probechem Biochemicals

Chemical Structure : VU6047534

VU6047534 (VU 6047534)

Catalog No.: PC-21829Not For Human Use, Lab Use Only.

VU6047534 is a selective, peripherally restricted 5-HT2B partial agonist with IC50 of 480 nM in radioligand binding assays.

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Biological Activity

VU6047534 is a selective, peripherally restricted 5-HT2B partial agonist with IC50 of 480 nM in radioligand binding assays.
VU6047534 shows high subtype selectivity relative to 5-HT2A and 5-HT2C (no significant inhibition up to 10 uM).
VU6047534 is peripherally restricted and able to both prevent and treat Sugen-hypoxia-induced pulmonary arterial hypertension.

Physicochemical Properties

M.Wt	351.42
Formula	C19H17N3O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(1-methyl-1H-indol-5-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

References

1. Valentine MS, et al.JACC Basic Transl Sci. 2023 Sep 13;8(10):1379-1388.

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VU6047534 (VU 6047534)

Biological Activity

Physicochemical Properties

References

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