Catalog No.: PC-35655Not For Human Use, Lab Use Only.
VU661013 (VU-661013) is a novel potent, selective MCL-1 inhibitor with Ki of 97 pM (human MCL-1) in TR-FRET assay, shows no significant inhibition on BCL-xL (Ki>40 uM) or BCL-2 (Ki=0.73 uM).
VU661013 (VU-661013) is a novel potent, selective MCL-1 inhibitor with Ki of 97 pM (human MCL-1) in TR-FRET assay, shows no significant inhibition on BCL-xL (Ki>40 uM) or BCL-2 (Ki=0.73 uM).
VU661013 de-stabilizes BIM/MCL-1 association, leads to apoptosis in AML.
VU661013 is active in venetoclax-resistant cells and patient derived xenografts.
