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VX-148

Chemical Structure : VX-148

CAS No.: 297730-05-3

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VX-148 (VX148)

Catalog No.: PC-35012Not For Human Use, Lab Use Only.

VX-148 (VX148) is a potent, uncompetitive, orally bioavailable IMPDH inhibitor with Ki of 6 nM against IMPDH type II enzyme.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    VX-148 (VX148) is a potent, uncompetitive, orally bioavailable IMPDH inhibitor with Ki of 6 nM against IMPDH type II enzyme.
    VX-148 is slightly more potent than VX-497 in inhibiting the proliferation of mitogen-stimulated primary human lymphocytes (IC50=80 nM).
    VX-148 inhibits primary antibody response in mice with ED50 value of 38 mg/kg b.i.d, significantly prolongs skin graft survival at 100 mg/kg b.i.d.

    Physicochemical Properties

    M.Wt 435.48
    Formula C23H25N5O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-1-cyanobutan-2-yl ((S)-1-(3-(3-(4-cyano-3-methoxyphenyl)ureido)phenyl)ethyl)carbamate

    References

    1. Jain J, et al. J Pharmacol Exp Ther. 2002 Sep;302(3):1272-7.

    2. Dunkern T, et al. J Enzyme Inhib Med Chem. 2014 Jun;29(3):408-19.

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