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Chemical Structure : VX-548
CAS No.: 2649467-58-1
Catalog No.: PC-22639Not For Human Use, Lab Use Only.
VX-548 (Suzetrigine) is a potent, highly selective and orally bioavailable inhibitor of NaV1.8 voltage-gated sodium channel with IC50 of 0.7 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $298 | In stock | |
| 2 mg | $488 | In stock | |
| 5 mg | $788 | In stock | |
| 10 mg | Get quote | ||
| 25 mg | Get quote |
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VX-548 (Suzetrigine) is a potent, highly selective and orally bioavailable inhibitor of NaV1.8 voltage-gated sodium channel with IC50 of 0.7 nM.
VX-548 (Suzetrigine) displays 31,000-fold selectivity over all other NaV subtypes (i.e., NaV1.1 to NaV1.7, and NaV1.9) in recombinant cells.
VX-548 (Suzetrigine) shows subnanomolar potency in primary neurons isolated from human dorsal-root ganglia.
In two phase 2 clinical trials of postoperative pain, as compared with placebo, the highest dose, but not lower doses, of VX-548 reduced pain over a 48-hour period.
| M.Wt | 473.40 | |
| Formula | C21H20F5N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-((2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carboxamido)picolinamide |
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1. Jones J, et al. N Engl J Med. 2023 Aug 3;389(5):393-405.
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