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Chemical Structure : VZ185
CAS No.: 2306193-61-1
Catalog No.: PC-35882Not For Human Use, Lab Use Only.
VZ185 (VZ-185) is a potent, fast and selective, VHL-based dual degrader probe (PROTAC) of BRD9 and BRD7 with DC50 of 1.8 and 4.5 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $198 | In stock | |
| 5 mg | $298 | In stock | |
| 10 mg | $468 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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VZ185 (VZ-185) is a potent, fast and selective, VHL-based dual degrader probe (PROTAC) of BRD9 and BRD7 with DC50 of 1.8 and 4.5 nM, respectively.
VZ185 induces strong and rapid degradation of of BRD9, BRD7 in a time- and dose-dependent manner after treatment of RI-1 cells, also shows a DC50 between 2-8 nM for BRD9 in a panel of other human cancer cell lines (EOL-1, A-204).
| M.Wt | 995.225 | |
| Formula | C53H67FN8O8S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2S,4R)-N-(2-((5-(4-(2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)piperazin-1-yl)pentyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide |
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1. Zoppi V, et al. J Med Chem. 2018 Dec 12. doi: 10.1021/acs.jmedchem.8b01413.
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