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Chemical Structure : Valdecoxib
CAS No.: 181695-72-7
Catalog No.: PC-20874Not For Human Use, Lab Use Only.
Valdecoxib (SC 65872) is a potent and selective inhibitor of COX-2 with IC50 of 5 nM, shows no activity against COX-1.
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Valdecoxib (SC 65872) is a potent and selective inhibitor of COX-2 with IC50 of 5 nM, shows no activity against COX-1.
Valdecoxib inhibits LPS-induced proliferation of endothelial cells and bFGF secretion in a dose-dependent manner.
Valdecoxib stimulates VEGF formation via HMEC-1 under inflammatory conditions. shows chronic antiinflammatory activity in the rat adjuvant arthritis model, with an ED50 of 0.032 mg/kg/day).
Valdecoxib (10 mg/kg, i.p.) significantly attenuates the behavioral and biochemical (oxidative damage) alterations in chronic-stressed mice.
Valdecoxib also selectively blocks rat TRPV2 channels in HEK293 and RBL-2H3 cells with IC50 of 9 and 11 uM, respectively, but not closely related TRPV1, TRPV3 or TRPV4 channels.
| M.Wt | 314.36 | |
| Formula | C16H14N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide |
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2. Kumar A, et al. Neurosci Bull. 2010 Feb;26(1):17-27.
3. Bluhm Y, et al. Eur J Pharmacol. 2022 Jan 15;915:174702.
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