Chemical Structure : Vamorolone
CAS No.: 13209-41-1
Catalog No.: PC-35648Not For Human Use, Lab Use Only.
Vamorolone (VBP15) is a dissociative steroidal compound, reduces NF-κB-mediated cytokine expression in vitro, also reduecs glucocorticoid-mediated side-effects when compared to dexamethasone in vivo.
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Vamorolone (VBP15) is a dissociative steroidal compound, reduces NF-κB-mediated cytokine expression in vitro, also reduecs glucocorticoid-mediated side-effects when compared to dexamethasone in vivo.
Vamorolone reduces NF-κB pathway inflammatory cytokines in mouse primary DIPG cells, shows efficacy in inducing an anti-inflammatory response in animal models of asthma, multiple sclerosis, inflammatory bowel disease, and muscular dystrophies, and has shown fewer side effects.
Vamorolone increases physical activity of tumor bearing mice.
M.Wt | 356.462 | |
Formula | C22H28O4 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
(8S,10S,13S,14S,16R,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-3-one |
1. Wells E, et al. Oncotarget. 2017 Feb 7;8(6):9366-9374.
2. Conklin LS, et al. Pharmacol Res. 2018 Sep 13;136:140-150.
3. Hoffman EP, et al. Steroids. 2018 Jun;134:43-52.
4. Almeida LEF, et al. Sci Rep. 2018 Apr 17;8(1):6081.
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