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Vamorolone

Chemical Structure : Vamorolone

CAS No.: 13209-41-1

Vamorolone (VBP-15, VBP15)

Catalog No.: PC-35648Not For Human Use, Lab Use Only.

Vamorolone (VBP15) is a dissociative steroidal compound, reduces NF-κB-mediated cytokine expression in vitro, also reduecs glucocorticoid-mediated side-effects when compared to dexamethasone in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Vamorolone (VBP15) is a dissociative steroidal compound, reduces NF-κB-mediated cytokine expression in vitro, also reduecs glucocorticoid-mediated side-effects when compared to dexamethasone in vivo.
Vamorolone reduces NF-κB pathway inflammatory cytokines in mouse primary DIPG cells, shows efficacy in inducing an anti-inflammatory response in animal models of asthma, multiple sclerosis, inflammatory bowel disease, and muscular dystrophies, and has shown fewer side effects.
Vamorolone increases physical activity of tumor bearing mice.

Physicochemical Properties

M.Wt 356.462
Formula C22H28O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(8S,10S,13S,14S,16R,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-3-one

References

1. Wells E, et al. Oncotarget. 2017 Feb 7;8(6):9366-9374.

2. Conklin LS, et al. Pharmacol Res. 2018 Sep 13;136:140-150.

3. Hoffman EP, et al. Steroids. 2018 Jun;134:43-52.

4. Almeida LEF, et al. Sci Rep. 2018 Apr 17;8(1):6081.

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