Chemical Structure : Vaniprevir
CAS No.: 923590-37-8
Catalog No.: PC-42481Not For Human Use, Lab Use Only.
A potent, selective, orally available inhibitor of HCV NS3/4A protease with Ki of 0.05 and 0.9 nM for GT1b and 2a protease, respectively.
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10 mg | $400 | In stock | |
50 mg | Get quote |
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A potent, selective, orally available inhibitor of HCV NS3/4A protease with Ki of 0.05 and 0.9 nM for GT1b and 2a protease, respectively; displays excellent selectivity against both a range of human proteases and a broad panel of pharmacologically relevant targets; has replicon EC50 of 3 and 9 nM for GT1b and 2a, respectively, has good plasma exposure and excellent liver exposure in multiple species.
HCV Infection
Approved
M.Wt | 757.9364 | |
Formula | C38H55N5O9S | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
Cyclopropanecarboxamide, N-[[[6-(2-carboxy-2,3-dihydro-1H-isoindol-4-yl)-2,2-dimethylhexyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethyl-, (12)-lactone, (1R,2R)- |
1. McCauley JA, et al. J Med Chem. 2010 Mar 25;53(6):2443-63.
2. Liverton NJ, et al. Antimicrob Agents Chemother. 2010 Jan;54(1):305-11.
3. Manns MP, et al. Hepatology. 2012 Sep;56(3):884-93.
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