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Vapendavir diphosphate

Chemical Structure : Vapendavir diphosphate

CAS No.: 1198151-75-5

Vapendavir diphosphate (BTA798 diphosphate)

Catalog No.: PC-21970Not For Human Use, Lab Use Only.

Vapendavir (BTA798) diphosphate is a novel potent enteroviral capsid binder, inhibits EV71 replication of all isolates with mean EC50 of 0.7 uM.

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Biological Activity

Vapendavir (BTA798) diphosphate is a novel potent enteroviral capsid binder, inhibits EV71 replication of all isolates with mean EC50 of 0.7 uM.
Vapendavir (BTA798) efficiently inhibits the in vitro replication of 21 EV71 strains/isolates that are representative of the different genogroups A, B, and C.
Vapendavir (BTA798) is currently under clinical study for the treatment of rhinovirus infections.

Physicochemical Properties

M.Wt 578.45
Formula C21H32N4O11P2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,2-Benzisoxazole, 3-ethoxy-6-[2-[1-(6-methyl-3-pyridazinyl)-4-piperidinyl]ethoxy]-, phosphate (1:2)

References

1. Tijsma A, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6990-2.

2. Sun L, et al. Antimicrob Agents Chemother. 2015 Dec;59(12):7782-5.

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