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Chemical Structure : Vardenafil
CAS No.: 224785-90-4
Catalog No.: PC-23407Not For Human Use, Lab Use Only.
Vardenafil is a potent, selective and orally active inhibitor of phosphodiesterase-5 (PDE5), inhibits the hydrolysis of cGMP by PDE5 with IC50 of 0.7 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $58 | In stock | |
| 50 mg | $88 | In stock | |
| 100 mg | $128 | In stock | |
| 250 mg | $218 | In stock | |
| 500 mg | Get quote |
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Vardenafil is a potent, selective and orally active inhibitor of phosphodiesterase-5 (PDE5), inhibits the hydrolysis of cGMP by PDE5 with IC50 of 0.7 nM.
Vardenafil shows weak inhibitory towards PDE1, PDE6 with IC50s of 180 nM, and 11 nM, while IC50s are >1000 nM for PDE3 and PDE4.
Vardenafil competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels.
| M.Wt | 488.61 | |
| Formula | C23H32N6O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one |
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1. Kim NN, et al. Life Sci. 2001 Sep 28;69(19):2249-56.
2. Saenz de Tejada I, et al. Int J Impot Res. 2001;13(5):282-290.
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