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Varlitinib

Chemical Structure : Varlitinib

CAS No.: 845272-21-1

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Varlitinib (ARRY-334543;ARRY334543)

Catalog No.: PC-42640Not For Human Use, Lab Use Only.

Varlitinib (ARRY-334543) is a potent, orally active, ATP-competitive, selective, reversible inhibitor of ErbB1 and ErbB2.

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10 mg $152 In stock
50 mg $432 In stock
100 mg $592 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Varlitinib (ARRY-334543) is a potent, orally active, ATP-competitive, selective, reversible inhibitor of ErbB1 and ErbB2; significantly reverses ABCG2-MDR by directly inhibiting the drug efflux function of ABCG2 at 1.0 uM; significantly reverses drug resistance mediated by ABCG2.

Thyroid Cancer

Approved

Physicochemical Properties

M.Wt 466.9433
Formula C22H19ClN6O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 16.67 mg/mL
Chemical Name/SMILES

4,6-Quinazolinediamine, N4-[3-chloro-4-(2-thiazolylmethoxy)phenyl]-N6-[(4R)-4,5-dihydro-4-methyl-2-oxazolyl]-

References

1. Wang DS, et al. J Cell Biochem. 2014 Aug;115(8):1381-91.

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