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Chemical Structure : Vebicorvir
Catalog No.: PC-49567Not For Human Use, Lab Use Only.
Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor, exhibits selective inhibition of HBV DNA replication with EC50 from 173 nM to 307 nM.
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Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor, exhibits selective inhibition of HBV DNA replication with EC50 from 173 nM to 307 nM.
Vebicorvir (ABI-H0731) ABI-H0731 suppressed covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC50s from 1.84 μM to 7.3 μM.
Vebicorvir (ABI-H0731) modulates the function of HBV core protein by promoting the assembly of aberrant capsids, blocking the encapsidation of pgRNA, and inhibiting the subsequent replication of HBV DNA, which ultimately leads to the inhibition of the production of mature viral particles.
Vebicorvir (ABI-H0731) showed broad-spectrum activity against genotypes A, B, C, and D with EC50 values from 86 to 142 nM.
Vebicorvir (ABI-H0731) exhibits pangenotypic activity and is additive to moderately synergistic when combined with NRTI entecavir (ETV).
| M.Wt | 467.437 | |
| Formula | C19H12F3N3O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Huang Q, et al. Antimicrob Agents Chemother. 2020 Oct 20;64(11):e01463-20.
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