Vecabrutinib (SNS-062) is a potent, reversible, non-covalent BTK inhibitor with IC50 of 2.9 and 4.4 nM for WT BTK and C481S BTK, respectively.
Vecabrutinib (SNS-062) binds to Tec kinase family members BTK (Kd=0.3 nM) and ITK (Kd=2.2 nM), but not bind EGFR, active in vitro in cells with the C481S mutation.
Vecabrutinib (SNS-062) inhibits pBTK in human whole blood with IC50 of 50 nM, demonstrates favorable pharmacokinetic properties.
Vecabrutinib (SNS-062) shows potential for overcoming the ibrutinib resistance due to C481S mutantion in BTK.
Physicochemical Properties
M.Wt
529.925
Formula
C22H24ClF4N7O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Room temperature in continental US; may vary elsewhere
