Chemical Structure : Vedroprevir
CAS No.:
1098189-15-1
Vedroprevir
(GS9451, GS-9451)
Catalog No. : PC-63007Not For Human Use, Lab Use Only.
Vedroprevir (GS-9451) is a potent HCV NS3/4A protease inhibitor with Ki of 0.41 nM, inhibits HCV GT-1b NS3/4A with IC50 of 3.2 nM in enzymatic assays.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6300701
Biological Activity
Vedroprevir (GS-9451) is a potent HCV NS3/4A protease inhibitor with Ki of 0.41 nM, inhibits HCV GT-1b NS3/4A with IC50 of 3.2 nM in enzymatic assays.
Physicochemical Properties
M.Wt
910.525
Formula
C45H60ClN7O9S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(1R,2R)-1-((2S)-1-((S)-2-(((((1R,3r,5S)-bicyclo[3.1.0]hexan-3-yl)oxy)carbonyl)amino)-3,3-dimethylbutanoyl)-4-((8-chloro-2-(2-(isopropylamino)thiazol-4-yl)-7-(2-morpholinoethoxy)quinolin-4-yl)oxy)pyrrolidine-2-carboxamido)-2-ethylcyclopropane-1-carboxylic
References
1. Sheng XC, et al. Bioorg Med Chem Lett.
2. Dvory-Sobol H, et al. Antimicrob Agents Chemother.
3. Yang H, et al. Antimicrob Agents Chemother.
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