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Chemical Structure : Veliparib dihydrochloride
CAS No.: 912445-05-7
Catalog No.: PC-42353Not For Human Use, Lab Use Only.
Veliparib (ABT-888) dihydrochloride is a potent, BBB penetrant, and orally active PARP inhibitor with IC50 of 5.2 and 2.9 nM for PARP-1 and PARP-2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $298 | In stock | |
| 250 mg | Get quote |
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Veliparib (ABT-888) dihydrochloride is a potent, BBB penetrant, and orally active PARP inhibitor with IC50 of 5.2 and 2.9 nM for PARP-1 and PARP-2, respectively.
Veliparib (ABT-888) displays no activity against SIRT2 and selective biochemical profile in a panel of 74 receptor-binding assays.
Veliparib (ABT-888) strongly potentiates temozolomide in the B16F10 s.c. murine melanoma model, also potentiates temozolomide, platinums, cyclophosphamide, and radiation in syngeneic and xenograft tumor models.
| M.Wt | 317.2142 | |
| Formula | C13H18Cl2N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 3.2 mg/mL |
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| Chemical Name/SMILES |
1H-Benzimidazole-7-carboxamide, 2-[(2R)-2-methyl-2-pyrrolidinyl]-, hydrochloride (1:2) |
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1. Donawho CK, et al. Clin Cancer Res. 2007 May 1;13(9):2728-37.
2. Albert JM, et al. Clin Cancer Res. 2007 May 15;13(10):3033-42.
3. Liu X, et al. Mol Cancer Res. 2008 Oct;6(10):1621-9.
4. Palma JP, et al. Anticancer Res. 2008 Sep-Oct;28(5A):2625-35.
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