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Chemical Structure : Velusetrag
Catalog No.: PC-62094Not For Human Use, Lab Use Only.
Velusetrag (TD-5108) is a potent, selective and oral 5-HT4 receptor agonist with pKi of 7.7, shows >500-fold selectivity over other 5-HT receptors.
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Velusetrag (TD-5108) is a potent, selective and oral 5-HT4 receptor agonist with pKi of 7.7, shows >500-fold selectivity over other 5-HT receptors.
Velusetrag (TD-5108) displays >25-fold selectivity over other biogenic amine receptors, and no effect on hERG channels.
Velusetrag (TD-5108) increases the contractility of the canine antrum, duodenum and jejunum with higher potency than tegaserod, demonstrates robust in vivo activity in the guinea pig, rat and dog gastrointestinal tracts.
| M.Wt | 504.646 | |
| Formula | C25H36N4O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Beattie DT, et al. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):139-47.
2. Smith JA, et al. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):125-37.
3. Manini ML, et al. Neurogastroenterol Motil. 2010 Jan;22(1):42-9, e7-8.
4. Long DD, et al. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6048-52.
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