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Chemical Structure : Venadaparib
CAS No.: 1681017-83-3
Catalog No.: PC-38102Not For Human Use, Lab Use Only.
Venadaparib (IDX-1197) is a potent, selective PARP inhibitor with IC50 of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $158 | In stock | |
| 25 mg | $278 | In stock | |
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| 100 mg | Get quote |
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Venadaparib (IDX-1197) is a potent, selective PARP inhibitor with IC50 of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively.
IDX-1197 does not inhibits PARP5A (Tankyrase-1, IC50>10 uM), which belongs to the PARP family.
IDX-1197 significantly inhibited PARP1-mediated PAR expression in DNA damage-induced Hela cells.
IDX-1197 exhibits potent tumor growth inhibition in germline BRCA1-mutated ovarian cancer PDX model.
IDX-1197 shows improved antitumor activity against breast cancer PDX models, which included both germline BRCA-mutated and non-germline BRCA-mutated models, compared with olaparib and/or niraparib.
| M.Wt | 406.461 | |
| Formula | C23H23FN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(3-(3-((cyclopropylamino)methyl)azetidine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one |
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1. Myongjae Lee, et al. Abstract A106: Development of IDX-1197, a novel, selective, and highly potent PARP inhibitor. American Association for Cancer Research, 2018.
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